Jerome S. Brody, M.D.

Professor of Medicine
Director of BUSM Pulmonary Center

Medical School: University of Illinois
Internship: Michael Reese Hospital
Residency: Michael Reese Hospital and University of Oklahoma
Fellowship: University of Pennsylvania
Board Certifications: Internal Medicine

jbrody AT bu.edu


Research Interests:

  • Genomics of smoking-related lung diseases
  • Lung cancer diagnostic/prognostic tools
  • Genomics and the pathogenesis of COPD
  • Developmental biology of the lung
  • Relation of lung cancer to lung development
 

Selected Publications:

  1. Spira,A., Beane,J., Shah,V., Liu,G., Steiling,K., Schembri,F., Gilman,S., Dumas,M., Sridhar,S., Keane,J., Calner,P., Beamis,J., Lenburg,M., Brody,J.S. Airway epithelial cell gene expression; A new diagnostic test for lung cancer in smokers. In preparation.
  2. Xiang,F., Lee,F.E-H, Cardoso,W., Yu,Q., Brody,J.S., Xiao,Z-X. Inhibition of E2F in lung epithelial cells disrupts mouse embryonic lung development. Submitted 2005.
    Brody,JS, Spira,A. Inflammation, Lung Cancer and COPD. In Press 2005.
  3. Shah,V., Sridhar,S., Beane,J., Brody,J.S., Spira,A. SIEGE: Smoking-induced epithelial gene expression database. Nucl. Acid Res.33:D573-D579,2005.
  4. Spira,A., Beane,J., Shah,V., Liu,G., Schembri,F., Yang,X., Palma,J. Brody, JS. Effects of cigarette smoke on the human airway epithelial cell transcriptome. PNAS. 101:10143-10148,2004..
  5. Spira,A, Beane,J., Pinto-Plata,V., Kadar,A., Liu,G., Celli,B, Brody,J.S. Gene expression profiling of human lung tissue from smokers with severe emphysema. Am. J. Respir. Cell Mol. Biol. 31: 601-610, 2004.
  6. Spira,A.,Beane,J.,Schembri,F.,Liu,G.,Ding,C.,Gilman,S.,Yang,X.,Cantor,C.,Brody,J.S. Noninvasive method for obtaining RNA from buccal mucosal epithelial cells for gene expression profiling. Biotechniques 36:484-87,2004
  7. Powell, C.A.,Caracta,C.,Bueno,R.,Richards,W.G.,Sugarbaker,D.J.,Brody,J.S. Patterns of allelic loss differ in lung adenocarcinomas of smokers and non-smokers. Lung Cancer. 39(1):23-9, 2003
  8. Powell,C.A.,Spira,A.,Derti,A.,DeLisi,C.,Busch,S.,Sugarbaker,D.J.,Bueno,R.,Brody,J.S. Gene expression profiles suggest different mechanisms in origin of lung adenocarcinoma in smokers and non-smokers. Am.J.Respir.Cell.Mol.Biol. 29:157-162, 2003.
  9. Borczuk,A, Kim, H, Xu,G-L, Busch,S., Filmus,J., Capurro,M., Brody,JS, Lange,J., D”Armiento,J.M., Rothmans,P.B., Powell,C.A. The heparan sulfate proteoglycan GPC3 is a potential lung tumor suppressor. Am.J.Respir.Cell Mol.Biol.29:694-701, 2003
  10. Charles,A.,Tang,X.,Crouch,E.,Brody,J.S.,Xiao,Z-X. Retinoblastoma protein functions as a co-activator of C/EBP-mediated regulation of surfactant protein D gene expression. J.Cell.Biochem.99:1-12, 2001.

 

 Information retrieved from: www.bumc.bu.edu/pulmonary/people/jeromebrody/